Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase, putative | 0.0374 | 1 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0262 | 0.6544 | 0.6544 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0374 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0374 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0262 | 0.6544 | 0.4913 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0374 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0262 | 0.6544 | 0.4913 |
Schistosoma mansoni | histone deacetylase | 0.0374 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0262 | 0.6544 | 0.4913 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.6544 | 0.4913 |
Echinococcus granulosus | histone deacetylase | 0.0262 | 0.6544 | 0.4913 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0268 | 0.6727 | 0.5182 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.3207 | 0.3207 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0268 | 0.6727 | 0.5182 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0374 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 1 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0374 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0262 | 0.6544 | 0.4913 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0374 | 1 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.0262 | 0.6544 | 0.4913 |
Echinococcus granulosus | histone deacetylase 6 | 0.0268 | 0.6727 | 0.5182 |
Leishmania major | histone deacetylase, putative | 0.0374 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0374 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0374 | 1 | 0.5 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0153 | 0.3207 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0262 | 0.6544 | 0.6544 |
Echinococcus multilocularis | histone deacetylase | 0.0262 | 0.6544 | 0.4913 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0374 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0262 | 0.6544 | 0.4913 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0374 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0374 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0374 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0262 | 0.6544 | 0.4913 |
Echinococcus granulosus | histone deacetylase 1 | 0.0374 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0374 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.2043 | 0.2043 |
Entamoeba histolytica | histone deacetylase, putative | 0.0374 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0374 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0374 | 1 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0262 | 0.6544 | 0.4913 |
Echinococcus granulosus | histone deacetylase 6 | 0.0262 | 0.6544 | 0.4913 |
Trypanosoma brucei | histone deacetylase 1 | 0.0374 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0262 | 0.6544 | 0.4913 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.6544 | 0.4913 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0374 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0262 | 0.6544 | 0.4913 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0374 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0374 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0153 | 0.3207 | 0.3207 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0153 | 0.3207 | 0.3207 |
Plasmodium falciparum | histone deacetylase 1 | 0.0374 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0262 | 0.6544 | 0.4913 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0374 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0374 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0262 | 0.6544 | 0.4913 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0374 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0262 | 0.6544 | 0.4913 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0374 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0262 | 0.6544 | 0.6544 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1861 | 0.1861 |
Loa Loa (eye worm) | histone deacetylase | 0.0262 | 0.6544 | 0.6544 |
Giardia lamblia | Histone deacetylase | 0.0374 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0262 | 0.6544 | 0.4913 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 78.69 % | Cytotoxicity against Homo sapiens (human) MOLT4 cells assessed as cell growth at 10 uM after 48 hr by SRB assay relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.