Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Neurotoxicity in ddY mouse assessed as elongation of hexobarbital-induced sleep at 300 mg/kg, po after 1 hr relative to diazepam | ChEMBL. | 24050790 | |
Activity (ADMET) | Neurotoxicity in ddY mouse assessed as reduction in locomotor activity at 10 to 100 mg/kg, po after 1 hr | ChEMBL. | 24050790 | |
Activity (ADMET) | Neurotoxicity in ddY mouse assessed as motor impairment at 10 to 100 mg/kg, po after 1 hr by horizontal rotarod test | ChEMBL. | 24050790 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.