Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1453 | 0.2623 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1453 | 0.2623 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0225 | 0.028 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0225 | 0.028 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0225 | 0.028 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1453 | 0.2623 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.1453 | 0.2623 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1453 | 0.2623 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.3867 | 0.7228 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0225 | 0.028 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0225 | 0.028 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1453 | 0.2623 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1453 | 0.2623 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0225 | 0.028 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1453 | 0.2623 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 87.86 % | Cytotoxicity against Homo sapiens (human) A549 cells assessed as cell viability at 10 uM after 72 hr by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.