Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | egl-9 family hypoxia-inducible factor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Neospora caninum | 2OG-Fe(II) oxygenase family protein, putative | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.004 | 0.007 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.0892 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0887 | 0.2692 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0056 | 0.012 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0887 | 0.2692 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0887 | 0.2692 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0887 | 0.2692 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0887 | 0.2692 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0887 | 0.2692 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0056 | 0.012 | 1 |
Echinococcus multilocularis | prolyl 4 hydroxylase subunit alpha 1 | 0.0017 | 0 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0887 | 0.2692 | 1 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.004 | 0.007 | 0.0259 |
Toxoplasma gondii | 5'-3' exonuclease, N-terminal resolvase family domain-containing protein | 0.002 | 0.0007 | 0.0025 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0887 | 0.2692 | 1 |
Schistosoma mansoni | prolyl 4-hydroxylase alpha subunit 1 | 0.0017 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0056 | 0.012 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.236 | 0.7254 | 1 |
Treponema pallidum | DNA polymerase I (polA) | 0.0056 | 0.012 | 0.5 |
Trypanosoma brucei | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.004 | 0.007 | 0.0259 |
Echinococcus granulosus | prolyl 4 hydroxylase subunit alpha 1 | 0.0017 | 0 | 0.5 |
Leishmania major | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.004 | 0.007 | 0.0259 |
Chlamydia trachomatis | DNA polymerase I | 0.0056 | 0.012 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0056 | 0.012 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.8 | Inhibition of PHD2 (unknown origin) by HTRF assay | ChEMBL. | 24055079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.