Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | 0.1218 | 0.7659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Chlamydia trachomatis | DNA polymerase I | 0.0056 | 0.0105 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0056 | 0.0105 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Brugia malayi | hypothetical protein | 0.1218 | 0.7659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0431 | 0.2545 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0431 | 0.2545 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0431 | 0.2545 | 1 |
Schistosoma mansoni | peroxidasin | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1218 | 0.7659 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.1218 | 0.7659 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0056 | 0.0105 | 0.5 |
Brugia malayi | Peroxidasin | 0.1218 | 0.7659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0431 | 0.2545 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1218 | 0.7659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1218 | 0.7659 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0431 | 0.2545 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1218 | 0.7659 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0431 | 0.2545 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1218 | 0.7659 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1218 | 0.7659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1218 | 0.7659 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0056 | 0.0105 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1218 | 0.7659 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0431 | 0.2545 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0431 | 0.2545 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0056 | 0.0105 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1218 | 0.7659 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0056 | 0.0105 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.7659 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.1218 | 0.7659 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | < 30 % | Inhibition of Angiotensin I converting enzyme(ACE) at the dose of 10 mg/kg (po) in rat | ChEMBL. | 2342054 |
Activity (binding) | = 50 % | Inhibition of Angiotensin I converting enzyme(ACE) at the dose of 10 mg/kg (ip) in rat | ChEMBL. | 2342054 |
Inhibition (binding) | < 20 % | In vitro inhibitory activity against Angiotensin I converting enzyme (ACE) | ChEMBL. | 2342054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.