Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Telomerase catalytic subunit | 0.1467 | 0.2623 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1467 | 0.2623 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1467 | 0.2623 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0226 | 0.0279 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0226 | 0.0279 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1467 | 0.2623 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1467 | 0.2623 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0226 | 0.0279 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1467 | 0.2623 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1467 | 0.2623 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1467 | 0.2623 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0226 | 0.0279 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.3903 | 0.7228 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0226 | 0.0279 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0226 | 0.0279 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 80 % | Inhibition of ACE (unknown origin) using Hippuryl-His-Leu as substrate at 10 ug incubated for 10 min prior to substrate addition measured after 45 min by spectrophotometric analysis relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.