Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Telomerase catalytic subunit | 0.0429 | 0.264 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0429 | 0.264 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0056 | 0.0235 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0429 | 0.264 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0056 | 0.0235 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0429 | 0.264 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0056 | 0.0235 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0429 | 0.264 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0429 | 0.264 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0056 | 0.0235 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0429 | 0.264 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0429 | 0.264 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0056 | 0.0235 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0056 | 0.0235 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.1142 | 0.7234 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.