Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0126 | 0.6806 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0019 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0055 | 0.2299 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.3361 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.014 | 0.7701 | 1 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.3361 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.3361 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.2299 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.2299 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.3361 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0126 | 0.6806 | 0.8837 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.3361 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0055 | 0.2299 | 0.684 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3361 | 0.3361 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3361 | 0.3361 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.014 | 0.7701 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3361 | 0.3361 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.014 | 0.7701 | 1 |
Brugia malayi | RNA binding protein | 0.0072 | 0.3361 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.2299 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.2299 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.2299 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0126 | 0.6806 | 0.8837 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.2299 | 0.684 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.2299 | 0.684 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0055 | 0.2299 | 0.2985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3361 | 0.3361 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0126 | 0.6806 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.2299 | 1 |
Treponema pallidum | NADH oxidase | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.3361 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3361 | 0.3361 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0126 | 0.6806 | 0.8837 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.2299 | 0.684 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0126 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.014 | 0.7701 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.3361 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.2299 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 11 mm | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition at 1.56 to 25 ug/mL | ChEMBL. | No reference |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition by serial plate dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.