Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone deacetylase 7A | 0.0058 | 0.4009 | 0.4009 |
Trypanosoma brucei | histone deacetylase 3 | 0.0058 | 0.4009 | 0.4009 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0054 | 0.3589 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.0058 | 0.4009 | 0.3025 |
Plasmodium falciparum | histone deacetylase 1 | 0.0075 | 0.5608 | 0.2668 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0058 | 0.4009 | 0.3025 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1412 | 0.1412 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.5608 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus granulosus | histone deacetylase 3 | 0.0075 | 0.5608 | 0.4886 |
Echinococcus multilocularis | histone deacetylase | 0.0058 | 0.4009 | 0.3025 |
Brugia malayi | Histone deacetylase family protein | 0.0058 | 0.4009 | 0.4009 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0058 | 0.4009 | 0.3025 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0123 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.5608 | 0.5608 |
Echinococcus granulosus | histone deacetylase 1 | 0.0075 | 0.5608 | 0.4886 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0058 | 0.4009 | 0.4009 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.4886 |
Leishmania major | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.003 | 0.1412 | 0.5 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0064 | 0.4578 | 0.3687 |
Loa Loa (eye worm) | histone deacetylase | 0.0058 | 0.4009 | 0.4009 |
Trypanosoma brucei | histone deacetylase 2 | 0.003 | 0.1412 | 0.1412 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0075 | 0.5608 | 0.4886 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0064 | 0.4578 | 0.3687 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1787 | 0.1787 |
Echinococcus granulosus | histone deacetylase 7 | 0.0058 | 0.4009 | 0.3025 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0075 | 0.5608 | 0.5608 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0064 | 0.4578 | 0.3687 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0123 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.5608 | 0.4886 |
Echinococcus granulosus | histone deacetylase | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma brucei | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0075 | 0.5608 | 0.4886 |
Trypanosoma brucei | histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.003 | 0.1412 | 0.1412 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.5608 | 0.4886 |
Brugia malayi | Histone deacetylase family protein | 0.0058 | 0.4009 | 0.4009 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0058 | 0.4009 | 0.3025 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus multilocularis | 0.0123 | 1 | 1 | |
Leishmania major | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.003 | 0.1412 | 0.1412 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0123 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Brugia malayi | histone deacetylase 11 | 0.003 | 0.1412 | 0.1412 |
Mycobacterium ulcerans | hypothetical protein | 0.0054 | 0.3589 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.5608 | 0.5608 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0123 | 1 | 1 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0123 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase, putative | 0.003 | 0.1412 | 0.1412 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1218 | 0.1218 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0075 | 0.5608 | 0.4886 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0075 | 0.5608 | 0.4886 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 64.4785804 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (ADMET) | = 84.64108065 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.