Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0123 | 1 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0075 | 0.5608 | 0.5608 |
Brugia malayi | histone deacetylase 11 | 0.003 | 0.1412 | 0.1412 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.5608 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1787 | 0.1787 |
Trypanosoma brucei | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.5608 | 0.5608 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 2 | 0.003 | 0.1412 | 0.1412 |
Leishmania major | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Trypanosoma cruzi | histone deacetylase, putative | 0.003 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.5608 | 0.4886 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.003 | 0.1412 | 0.1412 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0123 | 1 | 1 |
Echinococcus multilocularis | 0.0123 | 1 | 1 | |
Echinococcus granulosus | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus granulosus | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0123 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0058 | 0.4009 | 0.4009 |
Plasmodium vivax | histone deacetylase, putative | 0.0058 | 0.4009 | 0.3025 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0075 | 0.5608 | 0.4886 |
Echinococcus granulosus | histone deacetylase | 0.0058 | 0.4009 | 0.3025 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0058 | 0.4009 | 0.4009 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0064 | 0.4578 | 0.3687 |
Echinococcus granulosus | histone deacetylase 6 | 0.0064 | 0.4578 | 0.3687 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0123 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus multilocularis | histone deacetylase | 0.0058 | 0.4009 | 0.3025 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1218 | 0.1218 |
Echinococcus granulosus | histone deacetylase 1 | 0.0075 | 0.5608 | 0.4886 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0123 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.5608 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0075 | 0.5608 | 0.4886 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.4886 |
Leishmania major | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus granulosus | histone deacetylase 3 | 0.0075 | 0.5608 | 0.4886 |
Brugia malayi | Histone deacetylase family protein | 0.0058 | 0.4009 | 0.4009 |
Brugia malayi | Histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.003 | 0.1412 | 0.1412 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0075 | 0.5608 | 0.4886 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0058 | 0.4009 | 0.3025 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0058 | 0.4009 | 0.3025 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0075 | 0.5608 | 0.5608 |
Plasmodium falciparum | histone deacetylase 1 | 0.0075 | 0.5608 | 0.2668 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0075 | 0.5608 | 0.4886 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.5608 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0058 | 0.4009 | 0.4009 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.003 | 0.1412 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus granulosus | histone deacetylase 7 | 0.0058 | 0.4009 | 0.3025 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0054 | 0.3589 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0058 | 0.4009 | 0.4009 |
Trypanosoma brucei | histone deacetylase 4 | 0.0058 | 0.4009 | 0.4009 |
Mycobacterium ulcerans | hypothetical protein | 0.0054 | 0.3589 | 1 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0064 | 0.4578 | 0.3687 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma brucei | histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 64.4785804 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (ADMET) | = 84.64108065 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.