Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0055 | 0.0109 | 0.0109 |
Brugia malayi | Protein kinase domain containing protein | 0.0055 | 0.0109 | 0.0109 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0109 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0635 | 0.6823 | 1 |
Brugia malayi | Trypsin family protein | 0.0225 | 0.2073 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2073 | 0.2073 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.091 | 1 | 1 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.091 | 1 | 1 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0225 | 0.2073 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2073 | 0.2073 |
Brugia malayi | Kringle domain containing protein | 0.0055 | 0.0109 | 0.0109 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.091 | 1 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.091 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0055 | 0.0109 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.091 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.091 | 1 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0635 | 0.6823 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0055 | 0.0109 | 0.0109 |
Trichomonas vaginalis | pten, drome, putative | 0.0046 | 0 | 0.5 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0046 | 0 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0055 | 0.0109 | 0.0109 |
Onchocerca volvulus | 0.0225 | 0.2073 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0109 | 0.0109 |
Onchocerca volvulus | 0.0055 | 0.0109 | 0.0524 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0055 | 0.0109 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0225 | 0.2073 | 0.2073 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0046 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0055 | 0.0109 | 1 |
Onchocerca volvulus | 0.019 | 0.1668 | 0.8046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.