Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate dehydrogenase | 0.554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.554 | 1 | 1 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.554 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.2245 | 0.2316 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.554 | 1 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.554 | 1 | 1 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.554 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.5232 | 0.9281 | 0.9278 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.5232 | 0.9281 | 0.9278 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.554 | 1 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.554 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.