Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0073 | 0.051 | 0.0784 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0067 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.019 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0147 | 0.6507 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0073 | 0.051 | 0.0784 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0147 | 0.6507 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.019 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.019 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0067 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0073 | 0.051 | 0.0784 |
Toxoplasma gondii | prolyl endopeptidase | 0.0147 | 0.6507 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0147 | 0.6507 | 0.632 |
Trypanosoma brucei | prolyl endopeptidase | 0.0147 | 0.6507 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0073 | 0.051 | 0.0784 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0073 | 0.051 | 0.0784 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0147 | 0.6507 | 0.632 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0147 | 0.6507 | 0.632 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0119 | 0.4241 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.019 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.019 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0147 | 0.6507 | 0.632 |
Echinococcus granulosus | prolyl endopeptidase | 0.0147 | 0.6507 | 0.632 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | d 0 mg kg-1 | Ability of intraperitoneally administered compound (25 mg/kg) to antagonise apomorphine-induced aggression in male rats; d indicates toxic at 25 mg/Kg | ChEMBL. | 9379440 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.