Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0116 | 0.1128 | 0.1713 |
Trypanosoma cruzi | oligopeptidase b | 0.0116 | 0.1128 | 0.1713 |
Trypanosoma brucei | prolyl endopeptidase | 0.0271 | 0.6584 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0231 | 0.5163 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0116 | 0.1128 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0271 | 0.6584 | 0.6584 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0116 | 0.1128 | 0.1713 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0271 | 0.6584 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0196 | 0.3939 | 0.3939 |
Leishmania major | oligopeptidase b | 0.0116 | 0.1128 | 0.1713 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0116 | 0.1128 | 0.1713 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0116 | 0.1128 | 0.5 |
Trypanosoma brucei | oligopeptidase b | 0.0116 | 0.1128 | 0.1713 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0271 | 0.6584 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0368 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0271 | 0.6584 | 0.6584 |
Toxoplasma gondii | prolyl endopeptidase | 0.0271 | 0.6584 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0271 | 0.6584 | 0.6584 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0116 | 0.1128 | 0.1713 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0368 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0271 | 0.6584 | 0.6584 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0116 | 0.1128 | 0.1713 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0196 | 0.3939 | 0.3939 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0196 | 0.3939 | 0.3939 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0196 | 0.3939 | 0.5983 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0271 | 0.6584 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.6584 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0116 | 0.1128 | 0.1713 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0271 | 0.6584 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.12 ug cm**-2 | In vitro antibacterial activity was measured on gram positive bacteria S. aureus smith cell lines | ChEMBL. | 7932547 |
MIC (functional) | = 0.12 ug cm**-2 | In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 90-3 sensitive cell lines | ChEMBL. | 7932547 |
MIC (functional) | = 2 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-5 sensitive cell lines | ChEMBL. | 7932547 |
MIC (functional) | = 2 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-5 sensitive cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli PRP-1 tet-a(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 88-1 tet-B(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-C(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-D(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-4 tet-M(ribosomal protection) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 88-7 tet-k(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 90-1 tet-M(ribosomal protection) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli PRP-1 tet-a(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 88-1 tet-B(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-C(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-D(efflux resistance) cell lines | ChEMBL. | 7932547 |
MIC (functional) | > 32 ug cm**-2 | In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-4 tet-M(ribosomal protection) cell lines | ChEMBL. | 7932547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.