Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.1366 | 0.86 | 0.86 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0422 | 0.14 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.155 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.155 | 1 | 1 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.1366 | 0.86 | 0.86 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.155 | 1 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0422 | 0.14 | 0.14 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.155 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.