Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 0.1601 | 0.1601 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0366 | 1 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0366 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0346 | 0.9408 | 0.9408 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0077 | 0.1601 | 0.1601 |
Trypanosoma cruzi | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0128 | 0.3081 | 0.3081 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0366 | 1 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0045 | 0.0658 | 0.0658 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Leishmania major | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0128 | 0.3081 | 0.3081 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0366 | 1 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0077 | 0.1601 | 0.1601 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0148 | 0.3673 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0366 | 1 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase kinase, putative | 0.0128 | 0.3081 | 0.8389 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0077 | 0.1601 | 0.1601 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0077 | 0.1601 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0346 | 0.9408 | 0.9408 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0077 | 0.1601 | 0.1601 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 0.1601 | 0.1601 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0077 | 0.1601 | 0.1601 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 0.1601 | 0.1601 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0077 | 0.1601 | 0.1601 |
Trypanosoma brucei | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0128 | 0.3081 | 0.3081 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0366 | 1 | 1 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0366 | 1 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0045 | 0.0658 | 0.0658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.