Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0608 | 0.0627 |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.0608 | 0.038 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1385 | 0.1203 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9691 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0077 | 0.2813 | 0.2903 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0821 | 0.0848 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0821 | 0.0969 |
Brugia malayi | jmjC domain containing protein | 0.0106 | 0.4672 | 0.4685 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.2813 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.2813 | 0.2563 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0336 | 0.0089 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0821 | 0.0969 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.2813 | 0.2563 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.9691 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0183 | 0.9691 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0336 | 0.0089 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.2813 | 0.2629 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0039 | 0.0336 | 0.0347 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1385 | 0.143 |
Brugia malayi | Phospholipase A2 family protein | 0.0183 | 0.9691 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.2813 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0045 | 0.0717 | 0.0394 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.2813 | 0.2563 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1385 | 0.1203 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.2813 | 0.2629 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.0608 | 0.0627 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.2813 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0249 | 0.0257 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0106 | 0.4672 | 0.4487 |
Brugia malayi | jmjC domain containing protein | 0.0039 | 0.0336 | 0.0092 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0183 | 0.9691 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0045 | 0.0717 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1385 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1395 | 0.1439 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0067 | 0.2131 | 0.2199 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0188 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0084 | 0.3259 | 0.3086 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0106 | 0.4672 | 0.4487 |
Brugia malayi | Heterochromatin protein 1 | 0.0077 | 0.2813 | 0.2715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 10 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 days by Alamar blue assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.