Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0293 | 1 | 0.5 | |
Brugia malayi | cytochrome b | 0.005 | 0.028 | 1 |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.0293 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.005 | 0.028 | 0.1789 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0083 | 0.1566 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | cytochrome b | 0.0083 | 0.1566 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Plasmodium vivax | cytochrome b | 0.0083 | 0.1566 | 0.5 |
Loa Loa (eye worm) | cytochrome b | 0.005 | 0.028 | 0.5 |
Echinococcus granulosus | cytochrome B | 0.0083 | 0.1566 | 1 |
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.0293 | 1 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0083 | 0.1566 | 1 |
Plasmodium falciparum | cytochrome b | 0.0083 | 0.1566 | 0.5 |
Toxoplasma gondii | apocytochrome b, putative | 0.0083 | 0.1566 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.