Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0028 | 0.3872 | 0.3872 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0028 | 0.3872 | 0.1651 |
Toxoplasma gondii | kringle domain-containing protein | 0.0028 | 0.3872 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.3872 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0028 | 0.3872 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.3872 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.5303 | 0.5303 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.266 | 0.266 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0028 | 0.3872 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.5303 | 0.36 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3872 | 0.1651 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.5303 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0028 | 0.3872 | 0.3872 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0028 | 0.3872 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.3872 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.266 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0028 | 0.3872 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.