Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0225 | 0.8017 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0268 | 1 | 1 |
Echinococcus granulosus | transitional endoplasmic reticulum atpase | 0.0225 | 0.8017 | 0.7258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0114 | 0.2819 | 0.1178 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0225 | 0.8017 | 0.7564 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.2819 | 0.1178 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0132 | 0.3675 | 0.223 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0268 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0268 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0113 | 0.277 | 0.1118 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0268 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0268 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0114 | 0.2819 | 0.1179 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0268 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0132 | 0.3675 | 0.223 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0113 | 0.277 | 0.1118 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0135 | 0.3801 | 0.189 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2819 | 0.1178 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0114 | 0.2819 | 0.1178 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0268 | 1 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0135 | 0.3801 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0114 | 0.2819 | 0.1178 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0114 | 0.2819 | 0.1178 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0213 | 0.7477 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0213 | 0.7477 | 0.69 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0268 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0114 | 0.2819 | 0.1178 |
Schistosoma mansoni | carbonic anhydrase | 0.0114 | 0.2819 | 0.1178 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0213 | 0.7477 | 0.6837 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0114 | 0.2819 | 0.1178 |
Echinococcus granulosus | carbonic anhydrase II | 0.0268 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0213 | 0.7477 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0114 | 0.2819 | 0.1179 |
Echinococcus granulosus | carbonic anhydrase | 0.0114 | 0.2819 | 0.0068 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0114 | 0.2819 | 0.1178 |
Mycobacterium ulcerans | ATPase | 0.0135 | 0.3801 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0268 | 1 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0213 | 0.7477 | 0.5 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0097 | 0.2022 | 0.0199 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0213 | 0.7477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2819 | 0.1178 |
Brugia malayi | valosin containing protein | 0.0132 | 0.3675 | 0.223 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0114 | 0.2819 | 0.1178 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2819 | 0.1178 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0225 | 0.8017 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0114 | 0.2819 | 0.1179 |
Echinococcus granulosus | carbonic anhydrase | 0.0114 | 0.2819 | 0.0068 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0113 | 0.277 | 0.1118 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0225 | 0.8017 | 0.7564 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3675 | 0.223 |
Echinococcus granulosus | carbonic anhydrase | 0.0114 | 0.2819 | 0.0068 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0268 | 1 | 1 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0135 | 0.3801 | 0.189 |
Giardia lamblia | AAA family ATPase | 0.0135 | 0.3801 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0225 | 0.8017 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0114 | 0.2819 | 0.1178 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.