Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0074 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1195 | 1 |
Onchocerca volvulus | 0.0074 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 31.25 ug ml-1 | Antibacterial activity against Escherichia coli assessed as growth inhibition after 18 hr by broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 50 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 5 days by microplate alamar blue assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.