Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0633 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0633 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0633 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0633 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0633 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0633 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0633 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0633 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0633 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0633 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 50 % | Cytotoxicity against Homo sapiens (human) A549 cells at 250 mM by MTT assay relative to control | ChEMBL. | No reference |
MIC (functional) | = 0.5 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 21 days by broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 10536 after 24 hr by broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 16 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 24 hr by broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.