Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0828 | 0.2759 | 0.5 |
Onchocerca volvulus | 0.0828 | 0.2759 | 0.2771 | |
Onchocerca volvulus | 0.216 | 0.9959 | 1 | |
Onchocerca volvulus | 0.1842 | 0.824 | 0.8274 | |
Loa Loa (eye worm) | hypothetical protein | 0.216 | 0.9959 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0828 | 0.2759 | 0.2771 |
Schistosoma mansoni | hypothetical protein | 0.0828 | 0.2759 | 0.2759 |
Toxoplasma gondii | PAN domain-containing protein | 0.1343 | 0.5538 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0828 | 0.2759 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.216 | 0.9959 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0828 | 0.2759 | 0.2771 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0828 | 0.2759 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.216 | 0.9959 | 0.9959 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0828 | 0.2759 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0322 | 0.0021 | 0.0021 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0828 | 0.2759 | 0.5 |
Brugia malayi | Trypsin family protein | 0.216 | 0.9959 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0828 | 0.2759 | 0.2771 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0828 | 0.2759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0828 | 0.2759 | 0.2771 |
Mycobacterium ulcerans | hypothetical protein | 0.0318 | 0 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.1343 | 0.5538 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 ug ml-1 | Anticancer activity against Homo sapiens (human) MCF-7 cells assessed as inhibition of cell survival after 24 hr by MTT assay | ChEMBL. | No reference |
Survival (functional) | = 62.1 % | Anticancer activity against Homo sapiens (human) MCF-7 cells assessed as cell survival at 100 ug/ml after 24 hr by MTT assay (Rvb = 100%) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.