Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.074 | 1 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0382 | 0.5002 | 0.5 |
Brugia malayi | valosin containing protein | 0.0236 | 0.2965 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2965 | 0.1215 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0075 | 0.0716 | 0.1353 |
Brugia malayi | vesicle-fusing ATPase | 0.0236 | 0.2965 | 0.1215 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.074 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0403 | 0.5291 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0167 | 0.1993 | 0.3767 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0403 | 0.5291 | 0.5 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0241 | 0.3033 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0241 | 0.3033 | 0.0000097958 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0167 | 0.1993 | 0.3767 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0382 | 0.5002 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0382 | 0.5002 | 0.9453 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0236 | 0.2965 | 0.1215 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0382 | 0.5002 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0403 | 0.5291 | 1 |
Echinococcus granulosus | transitional endoplasmic reticulum atpase | 0.0403 | 0.5291 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0382 | 0.5002 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0075 | 0.0716 | 0.1353 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0075 | 0.0716 | 0.1353 |
Giardia lamblia | AAA family ATPase | 0.0241 | 0.3033 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.4948 | 0.3691 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0403 | 0.5291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.074 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.074 | 1 | 1 |
Mycobacterium ulcerans | ATPase | 0.0241 | 0.3033 | 0.5 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0403 | 0.5291 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.