Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0535 | 0.3122 | 0.2976 |
Echinococcus multilocularis | sphingosine kinase 1 | 0.1516 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0423 | 0.2334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0674 | 0.0476 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0423 | 0.2334 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0237 | 0.1031 | 0.1031 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0601 | 0.3587 | 0.3587 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0237 | 0.1031 | 0.1031 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0135 | 0.0318 | 0.0515 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1516 | 1 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0601 | 0.3587 | 0.3587 |
Mycobacterium tuberculosis | Conserved protein | 0.1516 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.1031 | 0.084 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0179 | 0.0624 | 0.1519 |
Entamoeba histolytica | hypothetical protein | 0.0356 | 0.1869 | 0.1602 |
Loa Loa (eye worm) | hypothetical protein | 0.1516 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0423 | 0.2334 | 0.2082 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0423 | 0.2334 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0423 | 0.2334 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0356 | 0.1869 | 0.1602 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0237 | 0.1031 | 0.3536 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0423 | 0.2334 | 1 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0255 | 0.1156 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0352 | 0.184 | 0.7551 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0336 | 0.1728 | 0.6995 |
Schistosoma mansoni | sphingosine kinase A B | 0.1516 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0423 | 0.2334 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0321 | 0.1621 | 0.6464 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.017 | 0.0566 | 0.0256 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0601 | 0.3587 | 0.3376 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0321 | 0.1621 | 0.6464 |
Loa Loa (eye worm) | hypothetical protein | 0.0352 | 0.184 | 0.1667 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0135 | 0.0318 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1516 | 1 | 0.5 |
Schistosoma mansoni | sphingoid long chain base kinase | 0.1516 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0407 | 0.2224 | 0.1969 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 30 to 300 mg/kg, ip measured at 0.5 hr by rotarod test | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, i.p. measured at 4 hr relative to control | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 0.25 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 1 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, ip measured at 2 hr relative to control | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 2 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, i.p. measured at 0.25 hr relative to control | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 4 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against scMET-induced clonic seizures at 30 to 300 mg/kg, ip measured at 0.5 to 4 hr | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as motor impairment at 100 mg/kg, ip measured at 0.5 hr by rotarod test relative to control | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, i.p. measured at 1 hr relative to control | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against 6 Hz psychomotor-induced clonic seizures at 100 mg/kg, i.p. measured at 0.5 hr relative to control | ChEMBL. | No reference | |
MED (functional) | = 300 mg kg-1 | Anticonvulsant activity in i.p. dosed Mus musculus (mouse) assessed as protection against maximal-electric shock-induced seizures measured at 0.5 hr | ChEMBL. | No reference |
MED (functional) | = 300 mg kg-1 | Anticonvulsant activity in i.p. dosed Mus musculus (mouse) assessed as protection against maximal-electric shock-induced seizures measured at 4 hr | ChEMBL. | No reference |
MTC (ADMET) | = 300 mg kg-1 | Neurotoxicity in i.p. dosed Mus musculus (mouse) assessed as motor impairment measured at 4 hr by rotarod test | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.