Detailed information for compound 1807088

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 222.173 | Formula: C10H7FN2O3
  • H donors: 2 H acceptors: 2 LogP: 1.36 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)c(=O)c(c(o2)N)C(=O)N
  • InChi: 1S/C10H7FN2O3/c11-4-1-2-6-5(3-4)8(14)7(9(12)15)10(13)16-6/h1-3H,13H2,(H2,12,15)
  • InChiKey: FGJFMEHJQPCJMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0181 0.4388 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0443 0.0443
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.148 0.148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0855 0.1949
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.2374 0.2374
Schistosoma mansoni hypothetical protein 0.0072 0.148 0.3372
Brugia malayi hypothetical protein 0.0324 0.818 0.818
Schistosoma mansoni hypothetical protein 0.0181 0.4388 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0855 0.1949
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0855 0.1949
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0443 0.1009
Echinococcus multilocularis geminin 0.0181 0.4388 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0 0.5
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0 0.5
Echinococcus granulosus GPCR family 2 0.0034 0.0443 0.1009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0855 0.0855
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0 0.5
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.0443 0.1009
Echinococcus multilocularis GPCR, family 2 0.0034 0.0443 0.1009
Loa Loa (eye worm) hypothetical protein 0.0324 0.818 0.818
Loa Loa (eye worm) hypothetical protein 0.0072 0.148 0.148
Schistosoma mansoni hypothetical protein 0.0034 0.0443 0.1009
Onchocerca volvulus TPPP family protein homolog 0.0392 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0443 0.0443
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0443 0.1009
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0855 0.1949
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0855 0.1949
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0 0.5
Loa Loa (eye worm) p25-alpha family protein 0.0392 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0443 0.1009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.2374 0.2374
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0443 0.0443
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0855 0.0855
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.0443 0.1009
Echinococcus granulosus geminin 0.0181 0.4388 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.2374 0.2374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0855 0.1949
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.2374 0.2374
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0443 0.0443
Schistosoma mansoni hypothetical protein 0.0034 0.0443 0.1009
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0443 0.1009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0855 0.1949

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.