Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0039 | 0.5569 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Mycobacterium leprae | Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) | 0.0038 | 0.5318 | 0.5 |
Loa Loa (eye worm) | transcriptional regulator | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.5569 | 0.5569 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0034 | 0.4321 | 0.776 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0055 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0055 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.5569 | 1 |
Leishmania major | NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe | 0.0055 | 1 | 1 |
Giardia lamblia | Transcriptional regulator, Sir2 family | 0.0055 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Trypanosoma brucei | Silent information regulator 2 related protein 3 | 0.0055 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0034 | 0.4321 | 0.4321 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0034 | 0.4318 | 0.7753 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.5569 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | transcriptional regulator | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0055 | 1 | 1 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0055 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Loa Loa (eye worm) | transcriptional regulator | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0055 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0034 | 0.4321 | 0.776 |
Entamoeba histolytica | protein kinase, putative | 0.0034 | 0.4321 | 0.4321 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | sirtuin 4 | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0055 | 1 | 1 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0055 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0034 | 0.4318 | 0.7753 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0055 | 1 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0055 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0034 | 0.4321 | 0.4321 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.