Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0014 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0019 | 0.0034 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0006 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0105 | 0.0099 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0124 | 0.0118 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0114 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0006 | 0.043 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.0124 | 0.0297 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0019 | 0.1414 |
Toxoplasma gondii | hypothetical protein | 0.2513 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0137 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1003 | 0.3977 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2513 | 1 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0006 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.2513 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0019 | 0.1145 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0006 | 0.043 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0019 | 0.1414 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0124 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2513 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0007 | 0.0006 | 0.043 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.0124 | 0.0297 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0114 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0019 | 0.0034 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0019 | 0.0034 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1003 | 0.3977 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0019 | 0.0034 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0137 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0006 | 0.043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12.5 nM | Displacement of [3H]LSD from human cloned 5-HT6 receptor expressed in HEK293 cells | ChEMBL. | 23036955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.