Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0553 | 1 | 1 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0553 | 1 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0553 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0553 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0553 | 1 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0553 | 1 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0553 | 1 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0553 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 500 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 after 24 to 48 hr by broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 1000 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 after 24 to 48 hr by broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.