Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | porphobilinogen synthase | 0.0414 | 1 | 0.5 |
Echinococcus multilocularis | delta aminolevulinic acid dehydratase | 0.0414 | 1 | 1 |
Mycobacterium ulcerans | delta-aminolevulinic acid dehydratase | 0.0414 | 1 | 0.5 |
Toxoplasma gondii | parasite porphobilinogen synthase PBGS | 0.0414 | 1 | 0.5 |
Onchocerca volvulus | 0.03 | 0.712 | 0.5 | |
Mycobacterium leprae | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) | 0.0414 | 1 | 0.5 |
Echinococcus granulosus | delta aminolevulinic acid dehydratase | 0.0414 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | delta-aminolevulinic acid dehydratase | 0.0414 | 1 | 0.5 |
Schistosoma mansoni | porphobilinogen synthase | 0.0414 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0016 | 0.0026 | 0.0037 |
Brugia malayi | hypothetical protein | 0.03 | 0.712 | 1 |
Plasmodium vivax | delta-aminolevulinic acid dehydratase, putative | 0.0414 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.712 | 1 |
Mycobacterium tuberculosis | Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) | 0.0211 | 0.4903 | 0.5 |
Schistosoma mansoni | porphobilinogen synthase | 0.0414 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of wild type Arabidopsis thaliana acetohydroxyacid synthase at 1 mg/L colorimetric assay | ChEMBL. | 22905906 |
Inhibition (binding) | = 0 % | Inhibition of wild type Arabidopsis thaliana acetohydroxyacid synthase at 3 mg/L colorimetric assay | ChEMBL. | 22905906 |
Inhibition (binding) | = 15 % | Inhibition of wild type Arabidopsis thaliana acetohydroxyacid synthase at 10 mg/L colorimetric assay | ChEMBL. | 22905906 |
Inhibition (binding) | = 55 % | Inhibition of wild type Arabidopsis thaliana acetohydroxyacid synthase at 100 mg/L colorimetric assay | ChEMBL. | 22905906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.