Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Mus musculus | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0292 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0292 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0292 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0292 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0292 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0803 | 0.7295 | 0.8549 |
Echinococcus granulosus | aminopeptidase N | 0.0993 | 1 | 1 |
Onchocerca volvulus | 0.0993 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0292 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0701 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.089 | 0.8533 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0292 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0292 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0993 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0292 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0292 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0292 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0292 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0292 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0292 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -6.99 | Binding affinity to CB2 receptor (unknown origin) | ChEMBL. | 17521177 |
Ki (binding) | = -6.77 | Binding affinity at CB1 receptor | ChEMBL. | 17980589 |
Ki (binding) | = -6.77 | Binding affinity to CB1 receptor (unknown origin) | ChEMBL. | 17521177 |
Ki (binding) | = 103 nM | Compound was tested for its binding affinity against mouse spleen Cannabinoid receptor 2 using [3H]CP-55,940 as radioligand | ChEMBL. | 12852753 |
Ki (binding) | = 103 nM | Binding affinity to CB2 receptor (unknown origin) | ChEMBL. | 17521177 |
Ki (binding) | = 103 nM | Compound was tested for its binding affinity against mouse spleen Cannabinoid receptor 2 using [3H]CP-55,940 as radioligand | ChEMBL. | 12852753 |
Ki (binding) | = 103 nM | Binding affinity to CB2 receptor (unknown origin) | ChEMBL. | 17521177 |
Ki (binding) | = 168 nM | Binding affinity against rat brain Cannabinoid receptor 1 using [3H]CP-55,940 | ChEMBL. | 12852753 |
Ki (binding) | = 168 nM | Binding affinity to CB1 receptor (unknown origin) | ChEMBL. | 17521177 |
Ki (binding) | = 168 nM | Binding affinity against rat brain Cannabinoid receptor 1 using [3H]CP-55,940 | ChEMBL. | 12852753 |
Ki (binding) | = 168 nM | Binding affinity to CB1 receptor (unknown origin) | ChEMBL. | 17521177 |
Log Ki (binding) | = 6.77 | Binding affinity at CB1 receptor | ChEMBL. | 17980589 |
Log Ki (binding) | = 6.77 | Binding affinity to CB1 receptor (unknown origin) | ChEMBL. | 17521177 |
Log Ki (binding) | = 6.99 | Binding affinity to CB2 receptor (unknown origin) | ChEMBL. | 17521177 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.