Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1317 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0021 | 0.0052 | 0.1145 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0073 | 0.0451 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.0503 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1317 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0021 | 0.0052 | 0.1145 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0073 | 0.0451 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0073 | 0.0451 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0377 | 0.0377 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0021 | 0.0052 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0021 | 0.0052 | 0.1028 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.0503 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0021 | 0.0052 | 0.1028 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0073 | 0.0451 | 0.0451 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.0414 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0021 | 0.0052 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0052 | 0.0052 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.0414 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1317 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1317 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0021 | 0.0052 | 0.1145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antibacterial activity against Escherichia coli MTCC 1652 assessed as growth inhibition at 4 mg/mL after 24 hr by agar well diffusion method | ChEMBL. | No reference | |
Inhibition (binding) | = 0 % | Inhibition of COX-2 (unknown origin) at 10 uM | ChEMBL. | No reference |
Inhibition (binding) | = 0 % | Inhibition of COX-1 (unknown origin) at 10 uM | ChEMBL. | No reference |
Inhibition (binding) | = 0 % | Inhibition of 5-LOX (unknown origin) at 10 uM | LITERATURE. | No reference |
IZ (functional) | = 14.6 mm | Antifungal activity against Saccharomyces cerevisiae MTCC 170 assessed as growth inhibition at 4 mg/mL after 24 hr by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 15.6 mm | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition at 4 mg/mL after 24 hr by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 64 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition after 24 hr by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 128 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae MTCC 170 assessed as growth inhibition after 24 hr by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.