Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | No references |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | No references |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 21.1 uM | Antiparasitic activity against Trichomonas vaginalis GT3 after 48 hr by Alamar blue assay | ChEMBL. | No reference |
Inhibition (binding) | Inhibition of COX1 (unknown origin) | LITERATURE. | No reference | |
Kd (binding) | = 0.0156 uM | Binding affinity to COX1 (unknown origin) | ChEMBL. | No reference |
Kd (binding) | = 0.0501 uM | Binding affinity to COX2 (unknown origin) | ChEMBL. | No reference |
MIC (functional) | = 19.3 uM | Antiparasitic activity against Trichomonas vaginalis GT3 after 48 hr by Alamar blue assay | ChEMBL. | No reference |
MIC (functional) | = 19.3 uM | Antiparasitic activity against Trichomonas vaginalis GT3 after 24 hr by Alamar blue assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.