Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | high affinity choline transporter 1 | 0.0361 | 1 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0095 | 0.112 | 0.5 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0156 | 0.3158 | 0.3158 |
Echinococcus granulosus | furin | 0.0156 | 0.3158 | 0.2295 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0156 | 0.3158 | 0.3002 |
Schistosoma mansoni | high-affinity choline transporter | 0.0361 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0176 | 0.3831 | 0.3053 |
Brugia malayi | celfurPC protein | 0.0126 | 0.2153 | 0.1055 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.3831 | 0.369 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0095 | 0.112 | 0.5 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0098 | 0.1227 | 0.0121 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0361 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.3831 | 0.369 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0098 | 0.1227 | 0.0121 |
Echinococcus granulosus | geminin | 0.0176 | 0.3831 | 0.3053 |
Echinococcus multilocularis | 0.0126 | 0.2153 | 0.1163 | |
Brugia malayi | endoprotease bli-4 precursor | 0.0156 | 0.3158 | 0.2201 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.3158 | 0.3158 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.