Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carbonic anhydrase-like protein | 0.0205 | 1 | 1 |
Giardia lamblia | DNA polymerase delta, catalytic subunit | 0.0153 | 0.5158 | 0.5 |
Loa Loa (eye worm) | DNA-directed DNA polymerase III | 0.0153 | 0.5158 | 0.5158 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0205 | 1 | 1 |
Entamoeba histolytica | DNA polymerase delta catalytic subunit, putative | 0.0153 | 0.5158 | 0.5 |
Plasmodium falciparum | DNA polymerase delta catalytic subunit | 0.0153 | 0.5158 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0205 | 1 | 1 |
Plasmodium vivax | DNA polymerase delta catalytic subunit, putative | 0.0153 | 0.5158 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0205 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0205 | 1 | 1 |
Echinococcus multilocularis | DNA polymerase delta catalytic subunit | 0.0153 | 0.5158 | 0.5158 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0205 | 1 | 1 |
Toxoplasma gondii | DNA polymerase | 0.0153 | 0.5158 | 1 |
Brugia malayi | DNA polymerase delta catalytic subunit | 0.0153 | 0.5158 | 0.5158 |
Onchocerca volvulus | DNA polymerase delta catalytic subunit homolog | 0.0153 | 0.5158 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0205 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0205 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0205 | 1 | 1 |
Echinococcus granulosus | DNA polymerase delta catalytic subunit | 0.0153 | 0.5158 | 0.5158 |
Schistosoma mansoni | DNA polymerase delta catalytic subunit | 0.0153 | 0.5158 | 0.5158 |
Trichomonas vaginalis | DNA polymerase zeta catalytic subunit, putative | 0.0153 | 0.5158 | 0.5 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0153 | 0.5158 | 0.3465 |
Echinococcus granulosus | carbonic anhydrase II | 0.0205 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DIZ (functional) | Antibacterial activity against Escherichia coli MTCC 1652 at 4 mg/ml after 24 hr by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.