Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclins, putative | 0.0168 | 0.0978 | 0.0978 |
Brugia malayi | cell division control protein 2 homolog | 0.0234 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.1543 | 0.1543 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0234 | 0.1635 | 0.1635 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0234 | 0.1635 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0234 | 0.1635 | 0.1635 |
Plasmodium falciparum | protein kinase 5 | 0.0234 | 0.1635 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0978 | 0.0978 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0234 | 0.1635 | 0.1635 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.1073 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0234 | 0.1635 | 0.1635 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.1073 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0234 | 0.1635 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0234 | 0.1635 | 0.1635 |
Plasmodium vivax | protein kinase Crk2 | 0.0234 | 0.1635 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0168 | 0.0978 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0279 | 0.0279 |
Echinococcus granulosus | cyclin dependent kinase | 0.0234 | 0.1635 | 0.1635 |
Giardia lamblia | Kinase, CMGC CDK | 0.0234 | 0.1635 | 0.1635 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0168 | 0.0978 | 0.0978 |
Brugia malayi | Protein kinase domain containing protein | 0.0234 | 0.1635 | 0.1635 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0234 | 0.1635 | 0.1635 |
Trichomonas vaginalis | cyclins, putative | 0.0168 | 0.0978 | 0.0978 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0234 | 0.1635 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0168 | 0.0978 | 0.0978 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0234 | 0.1635 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0978 | 0.0978 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0234 | 0.1635 | 0.1635 |
Trichomonas vaginalis | cyclin B, putative | 0.0168 | 0.0978 | 0.0978 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0234 | 0.1635 | 0.1635 |
Giardia lamblia | Kinase, CMGC CDK | 0.0234 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | TTK protein kinase | 0.1073 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0168 | 0.0978 | 0.0978 |
Trichomonas vaginalis | cyclin B, putative | 0.0168 | 0.0978 | 0.0978 |
Trichomonas vaginalis | cyclins, putative | 0.0168 | 0.0978 | 0.0978 |
Trichomonas vaginalis | cyclin B, putative | 0.0168 | 0.0978 | 0.0978 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0234 | 0.1635 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.1073 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0234 | 0.1635 | 0.1635 |
Schistosoma mansoni | cyclin B | 0.0168 | 0.0978 | 0.0978 |
Echinococcus multilocularis | cyclin B | 0.0168 | 0.0978 | 0.0978 |
Trichomonas vaginalis | cyclin B, putative | 0.0168 | 0.0978 | 0.0978 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0234 | 0.1635 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1073 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0234 | 0.1635 | 0.1635 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0234 | 0.1635 | 0.1635 |
Giardia lamblia | Kinase, TTK | 0.1073 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0234 | 0.1635 | 0.1635 |
Trichomonas vaginalis | cyclins, putative | 0.0115 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0234 | 0.1635 | 0.1635 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1073 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0234 | 0.1635 | 0.1635 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0234 | 0.1635 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0168 | 0.0978 | 0.0978 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0234 | 0.1635 | 0.1635 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0234 | 0.1635 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0234 | 0.1635 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0234 | 0.1635 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0168 | 0.0978 | 0.5981 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.1073 | 1 | 1 |
Echinococcus granulosus | cyclin B | 0.0168 | 0.0978 | 0.0978 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0234 | 0.1635 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-logMIC (functional) | = 3.55 | Antimicrobial activity against Escherichia coli ATCC 11230 after 24 hr by broth microdilution assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.