Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0093 | 0.112 | 0.5 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0096 | 0.1227 | 0.0121 |
Echinococcus multilocularis | 0.0123 | 0.2153 | 0.1163 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.3158 | 0.3158 |
Echinococcus granulosus | furin | 0.0153 | 0.3158 | 0.2295 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0153 | 0.3158 | 0.3158 |
Schistosoma mansoni | high-affinity choline transporter | 0.0354 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3831 | 0.369 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0173 | 0.3831 | 0.3053 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0354 | 1 | 1 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0153 | 0.3158 | 0.3002 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0354 | 1 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0093 | 0.112 | 0.5 |
Brugia malayi | celfurPC protein | 0.0123 | 0.2153 | 0.1055 |
Brugia malayi | endoprotease bli-4 precursor | 0.0153 | 0.3158 | 0.2201 |
Echinococcus multilocularis | geminin | 0.0173 | 0.3831 | 0.3053 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3831 | 0.369 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0096 | 0.1227 | 0.0121 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.