Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D1 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.4584 | 1 |
Giardia lamblia | AAA family ATPase | 0.0196 | 0.4742 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0311 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0311 | 0.9326 | 0.9122 |
Mycobacterium ulcerans | ATPase | 0.0196 | 0.4742 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0311 | 0.9326 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0311 | 0.9326 | 0.5 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0328 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0193 | 0.4584 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0328 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0311 | 0.9326 | 0.5 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0328 | 1 | 1 |
Brugia malayi | valosin containing protein | 0.0193 | 0.4584 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0328 | 1 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.0311 | 0.9326 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0311 | 0.9326 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0196 | 0.4742 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0193 | 0.4584 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0196 | 0.4742 | 0.0000097958 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0328 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0311 | 0.9326 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.17 nM | Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP production after 20 mins | ChEMBL. | 24296012 |
EC50 (binding) | = 83 nM | Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins | ChEMBL. | 24296012 |
Efficacy (binding) | = 95 % | Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins relative to dopamine | ChEMBL. | 24296012 |
Efficacy (functional) | = 96 % | Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP production after 20 mins relative to dopamine | ChEMBL. | 24296012 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.