Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hedgehog | 0.1304 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0492 | 0 | 0.5 |
Entamoeba histolytica | leucine-rich repeat domain-containing protein | 0.0492 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0492 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0492 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.095 | 0.5641 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0492 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 15.6 ug ml-1 | Antimicrobial activity against Escherichia coli CGMCC1.1571 after 24 hrs by twofold serial microdilution method | ChEMBL. | 24300736 |
MIC (functional) | = 31.2 ug ml-1 | Antimicrobial activity against Candida albicans CGMCC2.2086 after 48 hrs by twofold serial microdilution method | ChEMBL. | 24300736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.