Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0237 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0106 | 0 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0237 | 1 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0106 | 0 | 0.5 |
Plasmodium falciparum | protein kinase, putative | 0.0106 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0237 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0106 | 0 | 0.5 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0106 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0106 | 0 | 0.5 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0237 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0106 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0237 | 1 | 0.5 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0106 | 0 | 0.5 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0237 | 1 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0237 | 1 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0237 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | Cytotoxicity against human PC3 cells assessed as cell viability at 50 uM after 72 hrs by crystal violet method (Rvb = 95.69 +/- 7.66%) | ChEMBL. | 24387865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.