Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Galectin, carbohydrate recognition domain | 0.004 | 1 | 0.5 |
Onchocerca volvulus | Galectin homolog | 0.004 | 1 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | galectin | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 1 | 0.5 |
Onchocerca volvulus | Galectin homolog | 0.004 | 1 | 1 |
Brugia malayi | galectin | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 1 | 0.5 |
Brugia malayi | Galactoside-binding lectin family protein | 0.004 | 1 | 0.5 |
Brugia malayi | Galactoside-binding lectin family protein | 0.004 | 1 | 0.5 |
Brugia malayi | galectin | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | galectin | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 1 | 0.5 |
Echinococcus granulosus | Galectin carbohydrate recognition domain | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.004 | 1 | 0.5 |
Schistosoma mansoni | galectin | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.004 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 88.11 % | Cytotoxicity against human PC3 cells assessed as cell viability at 50 uM after 72 hrs by crystal violet method (Rvb = 95.69 +/- 7.66%) | ChEMBL. | 24387865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.