Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase type II | 0.0841 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0841 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0841 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0841 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0841 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0841 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0841 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0841 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0841 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0841 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0528 | 0.4537 | 0.4537 |
Echinococcus granulosus | hexokinase type 2 | 0.0841 | 1 | 0.5 |
Onchocerca volvulus | 0.0841 | 1 | 1 | |
Treponema pallidum | hexokinase (hxk) | 0.0841 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0841 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 0.5339 | 0.5339 |
Onchocerca volvulus | 0.0841 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.0841 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0841 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0841 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0841 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0841 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0528 | 0.4537 | 0.4537 |
Plasmodium vivax | hexokinase, putative | 0.0841 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0841 | 1 | 1 |
Onchocerca volvulus | 0.0841 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.0841 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0841 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0841 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0841 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0841 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0841 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 383 nM | Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay | ChEMBL. | 24360556 |
Potency (functional) | 0.3827 uM | PubChem BioAssay. Extended Characterization of HPGD Inhibitors: Activity in Primary Assay (HPGD). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.