Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0419 | 0.0419 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0162 | 0.0162 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.004 | 0.004 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0419 | 0.0419 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0419 | 0.0419 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.3281 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.3281 | 1 | 0.5 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0419 | 0.0419 |
Echinococcus multilocularis | 0.3281 | 1 | 1 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.004 | 0.004 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.004 | 0.004 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.004 | 0.004 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.1432 | 0.4288 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.3281 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0162 | 0.0162 |
Mycobacterium ulcerans | hypothetical protein | 0.1432 | 0.4288 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0419 | 0.0419 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.3281 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.004 | 0.004 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.004 | 0.004 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.004 | 0.004 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.004 | 0.004 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.3281 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | 0.0056 | 0.0035 | 0.0035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7300 nM | Inhibition of partially purified EGFR tyrosine kinase from human A431 cells | ChEMBL. | 17869510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.