Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0419 | 0.0419 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.004 | 0.004 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0419 | 0.0419 |
Mycobacterium ulcerans | hypothetical protein | 0.1432 | 0.4288 | 0.5 |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.004 | 0.004 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | 0.0056 | 0.0035 | 0.0035 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.004 | 0.004 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.1432 | 0.4288 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0419 | 0.0419 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.004 | 0.004 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0162 | 0.0162 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Echinococcus multilocularis | 0.3281 | 1 | 1 | |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.3281 | 1 | 0.5 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.3281 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.3281 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.004 | 0.004 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0045 | 0 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.3281 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0419 | 0.0419 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.004 | 0.004 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0419 | 0.0419 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.004 | 0.004 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.004 | 0.004 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7300 nM | Inhibition of partially purified EGFR tyrosine kinase from human A431 cells | ChEMBL. | 17869510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.