Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0398 | 0.2042 | 0.5 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0529 | 0.331 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0398 | 0.2042 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0398 | 0.2042 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0639 | 0.4379 | 0.1903 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0398 | 0.2042 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1109 | 0.8931 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0398 | 0.2042 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0187 | 0 | 0.5 |
Onchocerca volvulus | 0.0458 | 0.2623 | 0.5 | |
Onchocerca volvulus | Putative sulfate transporter | 0.0458 | 0.2623 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0398 | 0.2042 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0398 | 0.2042 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0187 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1219 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1219 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0398 | 0.2042 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0398 | 0.2042 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0398 | 0.2042 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0398 | 0.2042 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0398 | 0.2042 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2 nM | Agonist activity at human recombinant S1P1 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis | ChEMBL. | 24266709 |
EC50 (functional) | = 1000 nM | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis | ChEMBL. | 24266709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.