Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAR-related orphan receptor C | Starlite/ChEMBL | References |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutathione reductase | 0.005 | 0.0146 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0127 | 0.1532 | 0.1725 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0062 | 0.0359 | 0.2343 |
Entamoeba histolytica | protein kinase, putative | 0.0099 | 0.103 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.027 | 0.4103 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.0153 | 0.0374 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0099 | 0.103 | 0.1164 |
Brugia malayi | O-methyltransferase family protein | 0.0062 | 0.0359 | 0.0281 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0114 | 0.1302 | 0.1466 |
Loa Loa (eye worm) | O-methyltransferase | 0.0062 | 0.0359 | 0.0539 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.0146 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0051 | 0.0153 | 0.0374 |
Leishmania major | trypanothione reductase | 0.005 | 0.0146 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.2479 | 0.6041 |
Onchocerca volvulus | 0.0062 | 0.0359 | 0.5 | |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.005 | 0.0146 | 0.0164 |
Entamoeba histolytica | protein kinase, putative | 0.0099 | 0.103 | 0.5 |
Echinococcus granulosus | geminin | 0.018 | 0.2479 | 1 |
Loa Loa (eye worm) | glutaminase | 0.027 | 0.4103 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0114 | 0.1302 | 0.1466 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0127 | 0.1532 | 0.1725 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0359 | 0.0539 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.0146 | 0.0587 |
Brugia malayi | O-methyltransferase | 0.0062 | 0.0359 | 0.0281 |
Loa Loa (eye worm) | IRE protein kinase | 0.0099 | 0.103 | 0.2235 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.0146 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.0146 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0127 | 0.1532 | 0.1725 |
Loa Loa (eye worm) | glutaminase 2 | 0.027 | 0.4103 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0127 | 0.1532 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.0159 | 0.0387 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.2479 | 0.6041 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0042 | 0 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.027 | 0.4103 | 0.4103 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0472 | 0.7743 | 0.7743 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0472 | 0.7743 | 1 |
Schistosoma mansoni | glutaminase | 0.027 | 0.4103 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.0146 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0114 | 0.1302 | 0.1466 |
Schistosoma mansoni | o-methyltransferase | 0.0062 | 0.0359 | 0.0875 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0099 | 0.103 | 0.4155 |
Brugia malayi | O-methyltransferase family protein | 0.0062 | 0.0359 | 0.0281 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0114 | 0.1302 | 0.1466 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.0146 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0114 | 0.1302 | 0.1466 |
Onchocerca volvulus | 0.0062 | 0.0359 | 0.5 | |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0472 | 0.7743 | 0.8716 |
Brugia malayi | O-methyltransferase family protein | 0.0062 | 0.0359 | 0.0281 |
Mycobacterium tuberculosis | Probable methyltransferase | 0.0062 | 0.0359 | 0.0404 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.0536 | 0.8883 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0099 | 0.103 | 0.4155 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.0146 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.0146 | 0.0587 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0114 | 0.1302 | 0.1466 |
Schistosoma mansoni | o-methyltransferase | 0.0062 | 0.0359 | 0.0875 |
Schistosoma mansoni | o-methyltransferase | 0.0062 | 0.0359 | 0.0875 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0114 | 0.1302 | 0.85 |
Schistosoma mansoni | o-methyltransferase | 0.0062 | 0.0359 | 0.0875 |
Echinococcus multilocularis | geminin | 0.018 | 0.2479 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.027 | 0.4103 | 0.5209 |
Mycobacterium ulcerans | methyltransferase | 0.0062 | 0.0359 | 0.0359 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0062 | 0.0359 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 102 % | Inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide-induced APC-labeled RORgammat receptor ligand binding domain (unknown origin) after 1 hr by FRET assay | ChEMBL. | 24388993 |
IC50 (binding) | = 6.1 | Inhibition of RORgammat receptor ligand binding domain in mouse spleen CD4+ T cells assessed as inhibition of IL-17 production after 3 days by ELISA | ChEMBL. | 24388993 |
IC50 (binding) | = 7.4 | Inhibition of APC-labeled RORgammat receptor ligand binding domain (unknown origin) after 1 hr by FRET assay | ChEMBL. | 24388993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.