Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | suppression of tumorigenicity 14 (colon carcinoma) | Starlite/ChEMBL | References |
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Mastin | plasminogen activator, urokinase | 414 aa | 340 aa | 24.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0708 | 0.0708 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0708 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0035 | 0.0708 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0275 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0035 | 0.0708 | 0.0407 |
Onchocerca volvulus | 0.0275 | 1 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0275 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.0708 | 0.0407 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0275 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0.0708 | 0.0407 |
Onchocerca volvulus | 0.0275 | 1 | 1 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0035 | 0.0708 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0035 | 0.0708 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0035 | 0.0708 | 0.0407 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0275 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0708 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0708 | 0.0407 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0035 | 0.0708 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0275 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0275 | 1 | 1 |
Onchocerca volvulus | 0.0275 | 1 | 1 | |
Onchocerca volvulus | 0.0275 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0035 | 0.0708 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.2 uM | Inhibition of matriptase-SP1 (615 to 855) (unknown origin) expressed in Escherichia coli BL21(DE3) using Boc-Gln-Ala-Arg-7-amido-4-methyl coumarin hydrobromide as substrate by fluorescence assay | ChEMBL. | 24900621 |
Ki (binding) | > 10 uM | Inhibition of uPA (unknown origin) using L-PyroGlu-Gly-Arg-pNA.HCl as substrate | ChEMBL. | 24900621 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.