Detailed information for compound 1820315

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 525.984 | Formula: C26H28ClN5O5
  • H donors: 2 H acceptors: 6 LogP: 3.15 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CN(c1ccnc2c1cc(C(=O)NCc1ccc(cc1)Cl)c(=O)n2CC(=O)N1CC(C1)(C)C)C
  • InChi: 1S/C26H28ClN5O5/c1-26(2)14-31(15-26)21(33)12-32-23-18(20(8-9-28-23)30(3)13-22(34)35)10-19(25(32)37)24(36)29-11-16-4-6-17(27)7-5-16/h4-10H,11-15H2,1-3H3,(H,29,36)(H,34,35)
  • InChiKey: JRJGTRFONPWMJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 DNA polymerase No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Toxoplasma gondii DNA polymerase Get druggable targets OG5_127429 All targets in OG5_127429
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Neospora caninum DNA polymerase (EC 2.7.7.7), related Get druggable targets OG5_127429 All targets in OG5_127429
Cryptosporidium parvum DNA polymerase delta catalytic subunit. DNAQ-like 3-5 exonuclease; RNAseH fold Get druggable targets OG5_127429 All targets in OG5_127429
Schistosoma japonicum ko:K02327 DNA polymerase delta subunit 1, putative Get druggable targets OG5_127429 All targets in OG5_127429
Loa Loa (eye worm) DNA-directed DNA polymerase III Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma congolense DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Schistosoma mansoni DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania infantum DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania braziliensis DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans N terminus of DNA-directed DNA polymerase III (delta) Get druggable targets OG5_127429 All targets in OG5_127429
Cryptosporidium hominis DNA polymerase family B subunit Get druggable targets OG5_127429 All targets in OG5_127429
Brugia malayi DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Echinococcus granulosus DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Echinococcus multilocularis DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania major DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania donovani DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania mexicana DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans N terminus of DNA-directed DNA polymerase III (delta) Get druggable targets OG5_127429 All targets in OG5_127429
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium vivax DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Giardia lamblia DNA polymerase delta, catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Babesia bovis DNA polymerase delta subunit Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma brucei gambiense DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium falciparum DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Theileria parva DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium knowlesi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium yoelii DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans hypothetical protein Get druggable targets OG5_127429 All targets in OG5_127429
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0159 1 1
Brugia malayi Serotonin receptor 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus multilocularis sex peptide receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni neuropeptide receptor 0.0159 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0159 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0159 1 1
Schistosoma mansoni opsin-like receptor 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0159 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0159 1 1
Echinococcus granulosus neuropeptide s receptor 0.0159 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0159 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0159 1 1
Brugia malayi Serotonin receptor 0.0159 1 1
Echinococcus granulosus neuropeptide receptor 0.0159 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0159 1 1
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0092 0.4808 0.4808
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Echinococcus multilocularis neuropeptide receptor 0.0159 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0159 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0159 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Brugia malayi Dopamine receptor 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni neuropeptide receptor 0.0159 1 1
Brugia malayi hypothetical protein 0.0159 1 1
Brugia malayi hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0159 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0159 1 1
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0092 0.4808 0.4808
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0159 1 1
Schistosoma mansoni amine GPCR 0.0159 1 1
Echinococcus granulosus fmrfamide receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0159 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0159 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus multilocularis somatostatin receptor 0.0159 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0092 0.4808 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni amine GPCR 0.0159 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0159 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0159 1 1
Echinococcus granulosus g protein coupled receptor 0.0159 1 1
Schistosoma mansoni hypothetical protein 0.0159 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0159 1 1
Brugia malayi putative neuropeptide receptor 0.0159 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0159 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 1 1
Schistosoma mansoni opsin-like receptor 0.0159 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Toxoplasma gondii DNA polymerase 0.0092 0.4808 1
Echinococcus granulosus orexin receptor type 2 0.0159 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0159 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0159 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0159 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0159 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0159 1 1
Schistosoma mansoni neuropeptide receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni histamine h1 receptor 0.0159 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0159 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Brugia malayi hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0092 0.4808 0.4808
Echinococcus granulosus 7TM GPCR rhodopsin 0.0159 1 1
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0092 0.4808 1
Echinococcus multilocularis G protein coupled receptor 139 0.0159 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 1 1
Brugia malayi hypothetical protein 0.0159 1 1
Echinococcus granulosus allatostatin A receptor 0.0159 1 1
Schistosoma mansoni hypothetical protein 0.0159 1 1
Schistosoma mansoni neuropeptide receptor 0.0159 1 1
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0092 0.4808 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0159 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0159 1 1
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0092 0.4808 0.4808
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Brugia malayi hypothetical protein 0.0159 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0159 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0092 0.4808 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0159 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0159 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0159 1 1
Brugia malayi AKH receptor 0.0159 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 1 1
Brugia malayi GnHR receptor homolog 0.0159 1 1
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0092 0.4808 0.4808
Echinococcus multilocularis fmrfamide receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0159 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0159 1 1
Brugia malayi Dopamine receptor protein 2 0.0159 1 1
Brugia malayi ORL1-like opioid receptor 0.0159 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0159 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 1 1
Schistosoma mansoni biogenic amine receptor 0.0159 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0159 1 1
Echinococcus multilocularis allatostatin A receptor 0.0159 1 1
Brugia malayi G-protein coupled receptor 0.0159 1 1
Brugia malayi G-protein coupled receptor 0.0159 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0092 0.4808 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0159 1 1
Schistosoma mansoni amine GPCR 0.0159 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0159 1 1
Brugia malayi G protein-coupled receptor 0.0159 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus multilocularis serotonin receptor 0.0159 1 1
Brugia malayi neuropeptide F receptor 0.0159 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0159 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 1 1
Schistosoma mansoni opsin-like receptor 0.0159 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0159 1 1
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0092 0.4808 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0159 1 1
Brugia malayi hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 1 1
Echinococcus multilocularis fmrfamide receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Brugia malayi hypothetical protein 0.0159 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus granulosus g-protein coupled receptor 0.0159 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0159 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0159 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0159 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0159 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0159 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 1 1
Schistosoma mansoni amine GPCR 0.0159 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0159 1 1
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0075 0.3493 0.7266
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0159 1 1
Brugia malayi Melatonin receptor type 1A 0.0159 1 1
Brugia malayi hypothetical protein 0.0159 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0092 0.4808 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni biogenic amine receptor 0.0159 1 1
Brugia malayi DNA polymerase delta catalytic subunit 0.0092 0.4808 0.4808
Echinococcus granulosus somatostatin receptor 0.0159 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0159 1 1
Schistosoma mansoni biogenic amine receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Echinococcus granulosus hypothetical protein 0.0159 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0159 1 1
Echinococcus granulosus serotonin receptor 0.0159 1 1
Echinococcus multilocularis g protein coupled receptor 0.0159 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0159 1 1
Brugia malayi follicle stimulating hormone receptor 0.0159 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0159 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Schistosoma mansoni hypothetical protein 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0159 1 1
Schistosoma mansoni myosin xvIII 0.0159 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0159 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0159 1 1
Echinococcus granulosus sex peptide receptor 0.0159 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0159 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 1 1
Brugia malayi sulfakinin receptor protein 0.0159 1 1
Echinococcus multilocularis orexin receptor type 2 0.0159 1 1
Echinococcus multilocularis g protein coupled receptor 0.0159 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0159 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Brugia malayi neuropeptide F receptor 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0092 0.4808 1
Brugia malayi hypothetical protein 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus multilocularis neuropeptide receptor 0.0159 1 1
Echinococcus multilocularis g protein coupled receptor 0.0159 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0159 1 1
Echinococcus granulosus g protein coupled receptor 0.0159 1 1
Brugia malayi RE15519p 0.0159 1 1
Echinococcus multilocularis serotonin receptor 0.0159 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0159 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0159 1 1
Brugia malayi Dopamine receptor protein 1 0.0159 1 1
Schistosoma mansoni hypothetical protein 0.0159 1 1
Schistosoma mansoni amine GPCR 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus granulosus neuropeptide receptor 0.0159 1 1
Brugia malayi larval opioid receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Onchocerca volvulus 0.0159 1 1
Echinococcus granulosus g protein coupled receptor 0.0159 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Schistosoma mansoni adenoreceptor 0.0159 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0159 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0159 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0159 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 50 nM HCMV Polymerase LANCE TR-FRET Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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