Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0056 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0127 | 0.0067 | 0.8342 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.4165 | 0.3864 | 1 |
Schistosoma mansoni | hypothetical protein | 0.4165 | 0.3864 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0056 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.0018 | 0.0046 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.0018 | 0.0046 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0018 | 0.0046 |
Schistosoma mansoni | hypothetical protein | 0.4165 | 0.3864 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0141 | 0.008 | 1 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.4165 | 0.3864 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0127 | 0.0067 | 0.8342 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.4165 | 0.3864 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0141 | 0.008 | 1 |
Schistosoma mansoni | apoptosis regulator bax | 0.4165 | 0.3864 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0018 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.4165 | 0.3864 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0127 | 0.0067 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0056 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0127 | 0.0067 | 0.8342 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0018 | 0.0046 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0127 | 0.0067 | 0.8342 |
Leishmania major | trypanothione reductase | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.4165 | 0.3864 | 0.3864 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0141 | 0.008 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0127 | 0.0067 | 0.8342 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.0018 | 0.0018 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 1.0691 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.4165 | 0.3864 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0056 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0056 | 0 | 0.5 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.4165 | 0.3864 | 0.3864 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.0018 | 0.0018 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0141 | 0.008 | 1 |
Brugia malayi | RNA binding protein | 0.0074 | 0.0018 | 0.0046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.