Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0103 | 0.5 | 0.5 | |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0103 | 0.5 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0103 | 0.5 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0103 | 0.5 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | Mastin | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0103 | 0.5 | 0.5 | |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0103 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 86 % | Agonist activity at human recombinant CB2 receptor expressed in HEK293 cells coexpressing Galphaq/o5 assessed as calcium mobilization by FLIPR assay relative to CP-55940 | ChEMBL. | 19921781 |
EC50 (functional) | = 14 nM | Agonist activity at human recombinant CB2 receptor expressed in HEK293 cells coexpressing Galphaq/o5 assessed as calcium mobilization by FLIPR assay | ChEMBL. | 19921781 |
Ki (binding) | = 7.21 | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CHO cells | ChEMBL. | 19921781 |
Ki (binding) | = 8.59 | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells | ChEMBL. | 19921781 |
Ki (binding) | = 2.6 nM | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells | ChEMBL. | 19921781 |
Ki (binding) | = 62 nM | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CHO cells | ChEMBL. | 19921781 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.