Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0674 | 0.6992 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0674 | 0.6992 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0674 | 0.6992 | 1 |
Echinococcus multilocularis | lysosomal protective protein | 0.0674 | 0.6992 | 0.6992 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0111 | 0.099 | 0.1415 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0607 | 0.6281 | 0.8984 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0674 | 0.6992 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0674 | 0.6992 | 1 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0674 | 0.6992 | 1 |
Schistosoma mansoni | kinase | 0.0057 | 0.0405 | 0.058 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.099 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0674 | 0.6992 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0111 | 0.099 | 0.099 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0429 | 0.0613 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0674 | 0.6992 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.099 | 1 |
Giardia lamblia | Kinase, PLK | 0.0111 | 0.099 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.099 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.023 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.6992 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.099 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0429 | 0.0613 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.099 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.023 | 0.0329 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0674 | 0.6992 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0111 | 0.099 | 0.1415 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.023 | 0.0329 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.099 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0111 | 0.099 | 0.1415 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0674 | 0.6992 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0111 | 0.099 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0674 | 0.6992 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.099 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.099 | 1 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0674 | 0.6992 | 1 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0067 | 0.0512 | 0.0733 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0607 | 0.6281 | 0.6281 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0429 | 0.0613 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0674 | 0.6992 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0429 | 0.0613 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 60 % | Inhibition of recombinant human BACE1 using (7-methoxycoumarin-4-yl)acetyl-SEVNL*DAEFRK(2,4-dinitrophenyl)-RR-NH2) as substrate at 2 uM by FRET assay | ChEMBL. | 24360554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.