Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0229754 | 0.138129 | 1 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.113475 | 1 | 1 |
Onchocerca volvulus | 0.0229754 | 0.138129 | 1 | |
Entamoeba histolytica | protein kinase, putative | 0.113475 | 1 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0229754 | 0.138129 | 1 |
Onchocerca volvulus | 0.0229754 | 0.138129 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0229754 | 0.138129 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0229754 | 0.138129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014504 | 0.0574518 | 0.415928 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.113475 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.014504 | 0.0574518 | 0.415928 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0229754 | 0.138129 | 1 |
Onchocerca volvulus | 0.014504 | 0.0574518 | 0.415928 | |
Loa Loa (eye worm) | hypothetical protein | 0.014504 | 0.0574518 | 0.415928 |
Entamoeba histolytica | protein kinase, putative | 0.113475 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.113475 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.014504 | 0.0574518 | 0.415928 |
Loa Loa (eye worm) | hypothetical protein | 0.014504 | 0.0574518 | 0.415928 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.014504 | 0.0574518 | 0.415928 |
Loa Loa (eye worm) | hypothetical protein | 0.014504 | 0.0574518 | 0.415928 |
Onchocerca volvulus | 0.014504 | 0.0574518 | 0.415928 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.014504 | 0.0574518 | 0.415928 |
Onchocerca volvulus | 0.0229754 | 0.138129 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.014504 | 0.0574518 | 0.415928 |
Onchocerca volvulus | 0.0229754 | 0.138129 | 1 | |
Onchocerca volvulus | 0.0229754 | 0.138129 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.014504 | 0.0574518 | 0.415928 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.014504 | 0.0574518 | 0.415928 |
Onchocerca volvulus | 0.0229754 | 0.138129 | 1 | |
Onchocerca volvulus | 0.0229754 | 0.138129 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.014504 | 0.0574518 | 0.415928 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00847138 | 0 | 0.5 |
Onchocerca volvulus | 0.0229754 | 0.138129 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 73.3 uM | Antiparasitic activity against trypomastigote form of Trypanosoma cruzi Y infected in LLCMK2 cells assessed as parasite lysis after 24 hrs by Pizzi-Brener method | ChEMBL. | 24398381 |
IC50 (functional) | = 16.7 uM | Antiparasitic activity against epimastigote form of Trypanosoma cruzi Y after 96 hrs by hemocytometry | ChEMBL. | 24398381 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 24398381 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.